Table 2.
Thermodynamic parameters of the protonation of inhibitor sulfonamide group and hCA XIII zinc-bound hydroxide anion at 25°C
| Δb_protonH, kJ/mol | pKa | Ka, M | Δb_protonG, kJ/mol | TΔb_protonS, kJ/mol | Δb_protonS, J/(mol × K) | Δb_protonCp, J/(mol × K) | |
|---|---|---|---|---|---|---|---|
| EZA |
−29.5 |
8.0 |
1.0 × 10-8 |
−45.7 |
16.2 |
54.2 |
88.7 |
| TFMSA |
−23.9 |
6.25 |
5.6 × 10-7 |
−35.7 |
11.8 |
39.5 |
124.7 |
| AZMa |
−23.0 |
7.30 |
5.0 × 10-8 |
−41.7 |
18.7 |
62.6 |
ND |
| CA-Zn-H2O | −26.0 | 8.25 | 5.6 × 10-9 | −47.1 | 21.1 | 70.7 | ND |
Standard deviations are below 10% for all parameters measured in kJ/mol.
a – data taken from [30].