Figure 1. Fungal zinc acquisition.

(A) Schematic of zinc transporter phylogeny from selected fungal pathogens; S. cerevisiae is included for comparison. Note the presence of three clusters; only transporters of the third class (red dashed box) are encoded syntenically with the zincophore (Pra1). (B) An archetypal fungal cell acquires zinc via cell membrane transporters, intracellular mobilization of stored zinc, and a zincophore scavenging system. Note that the third class of transporter (red) also mediates zincophore reassociation.