Table 3.
Estimates of dose of fluticasone (μg/day) giving peak effect and effect on mean change in outcome measure
| Outcome measure | Fixed effects model
|
Random effects model
|
||||
|---|---|---|---|---|---|---|
| R2 | Dose of peak effect | Mean change (95% CI) | Dose of peak effect | Mean change (95% CI) | ||
| FEV1 (l) | 35% | 568 | 0.62 (0.24 to 1.00) | 628 | 0.70 (0.24 to 1.17) | |
| Morning PEF (l/min) | 48% | 600 | 44 (19.5 to 68.5) | 633 | 50 (14.5 to 86.1) | |
| Evening PEF (l/min) | 49% | 590 | 52 (8.6 to 95.0) | 657 | 51 (12.6 to 89.7) | |
| β agonist use (puffs/day) | 35% | 560 | −1.98 (−3.00 to −0.93) | 574 | −2.36 (−4.05 to −0.66) | |
FEV1=forced expiratory volume in one second; PEF=peak expiratory flow.