Table 2.
Number of drug targets present in isolated components in the full and reliable subsets
| Network | # Connected components | # Proteins in disconnected components | # Drug targets in disconnected components |
|---|---|---|---|
| Full PIN |
140 |
324 |
7 |
| B subset |
139 |
354 |
12 |
| Non-predicted subset |
164 |
376 |
12 |
| MI score - IntAct |
75 |
207 |
18 |
| LTP subset |
188 |
428 |
27 |
| MI score - PSICQUIC | 138 | 372 | 41 |
The full PIN contains 7 drug targets that are disconnected from the main component. This number increases as interactions are removed to generate subsets of the data that are potentially more reliable; i.e., more drug targets become disconnected from the largest component of the network.