Table 3.

Sensitivity, specificity, positive predictive values, and positive likelihood ratios for 3 depression screening tools in adults with glioma

Screening Tool and Threshold	T1				T2				T3
	Sensitivity	Specificity	PPV	LR+	Sensitivity	Specificity	PPV	LR+	Sensitivity	Specificity	PPV	LR+
DTa ≥
4	0.90	0.72	0.32	3.2	0.94	0.75	0.41	3.7	0.67	0.69	0.14	2.1
5	0.80	0.84	0.42	4.9	0.81	0.80	0.45	4.2	0.67	0.82	0.22	3.7
6	0.60	0.90	0.46	5.8	0.75	0.85	0.50	5.0	0.67	0.88	0.31	5.7
7	0.50	0.96	0.63	11.1	0.62	0.87	0.50	5.0	0.50	0.92	0.33	6.4
HAD-Db ≥
6	0.93	0.805	0.38	4.8	1.00	0.85	0.52	6.5	0.80	0.84	0.25	5.0
7	0.93	0.907	0.56	10.0	1.00	0.88	0.59	8.7	0.80	0.88	0.31	6.7
8	0.73	0.924	0.55	9.6	0.92	0.92	0.67	12.0	0.60	0.89	0.27	5.6
9	0.73	0.958	0.69	17.4	0.77	0.96	0.77	20.2	–c	–	–	–
10	0.60	0.958	0.64	14.3	0.69	0.99	0.90	53.2	0.40	0.96	0.40	10.0
11	0.40	0.975	0.67	16.0	0.62	0.99	0.89	47.3	0.20	0.96	0.25	5.0
PHQ-9d ≥
8	1.00	0.68	0.29	3.1	0.93	0.84	0.52	5.7	0.83	0.80	0.26	4.2
9	0.93	0.75	0.33	3.7	0.71	0.86	0.50	5.2	0.83	0.83	0.29	4.9
10	0.80	0.86	0.43	5.7	0.71	0.89	0.56	6.5	0.67	0.83	0.25	3.9
11	0.73	0.87	0.42	5.6	0.71	0.93	0.67	10.5	0.67	0.89	0.33	5.9

T1, T2, T3 are first, second, and third sampling timepoints, respectively. LR⁺ = likelihood ratio of the probability of screening positive when MDD is present to the probability of screening positive when MDD is absent.

Patients received a Structured Clinical Interview for DSM-IV depression at each timepoint. Boxed figures indicate the best balance of operating characteristics at each timepoint.

^aT1 n = 154, T2 n = 103, T3 n = 83.

^bT1 n = 133, T2 n = 91, T3 n = 80.

^cNo patient scored a total of 9 on this scale at this timepoint.

^dT1 n = 129, T2 n = 87, T3 n = 77.