Table 2.
Univariate and multivariate analyses of OS, DFS and PFS in relation to clinical parameters and Trop-2 protein expression
| |
OS |
DFS |
PFS |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variables | N=97 | HR | 95%CI | p | N=93 | HR | 95%CI | p | N=97 | HR | 95%CI | p |
|
Univariate analysis | ||||||||||||
|
Age |
|
|
|
|
|
|
|
|
|
|
|
|
| <65 vs ≥65 |
103 |
1.23 |
0.46-3.28 |
0.68 |
93 |
1.06 |
0.41-2.75 |
0.90 |
102 |
1.37 |
0.49-3.79 |
0.54 |
|
FIGO stage |
|
|
|
|
|
|
|
|
|
|
|
|
| III-IV vs I-II |
97 |
17.05 |
5.47-53.17 |
<0.01 |
93 |
5.88 |
2.25-15.34 |
<0.01 |
96 |
16.73 |
5.28-53.03 |
<0.01 |
|
Tumor grade |
|
|
|
|
|
|
|
|
|
|
|
|
| G1 vs G2-G3 |
103 |
0.001 |
-* |
0.68 |
99 |
0.155 |
0.02-1.18 |
0.07 |
102 |
0.001 |
-* |
0.69 |
|
Lymph node involvement |
|
|
|
|
|
|
|
|
|
|
|
|
| positive vs negative |
87 |
10.17 |
3.22-32.11 |
<0.01 |
85 |
6.05 |
2.09-17.51 |
<0.01 |
86 |
14.07 |
4.08-48.49 |
<0.01 |
|
Trop-2 IHC |
|
|
|
|
|
|
|
|
|
|
|
|
| score=3 vs score 0/1/2 |
103 |
2.60 |
0.94-7.19 |
0.06 |
99 |
3.36 |
1.26-8.92 |
0.01 |
102 |
2.80 |
0.99-7.87 |
0.05 |
|
Multivariate analysis | ||||||||||||
|
Trop-2 IHC |
97 |
|
|
|
93 |
|
|
|
97 |
|
|
|
| score=3 vs score 0/1/2 |
|
1.83 |
0.65-5.18 |
0.25 |
|
2.82 |
1.05-7.58 |
0.04 |
|
1.76 |
0.63-4.88 |
0.28 |
|
FIGO stage |
97 |
|
|
|
93 |
|
|
|
97 |
|
|
|
| III-IV vs I-II | 15.94 | 5.08-50.04 | <0.001 | 5.36 | 2.04-14.08 | <0.001 | 16.73 | 5.31-52.73 | <0.001 | |||
*Because of the small number of events (deaths and progressions) in the G1 EEC category, the confidence interval was not reliable.