Table 4.
Genetic frequency of the genotypes of eight SNPs in six genes and their association with infection by influenza A/H1N1 virus
|
Gene and genotype |
Genetic frequency |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| A/H1N1 group | AHC group | p | OR | 95% CI | ILI group | p | OR | 95% CI | |
|
CCL1 rs2282691 |
|
|
|
|
|
|
|
|
|
| AA |
0.643 |
0.402 |
0.0085 |
2.67 |
1.26-5.81 |
0.630 |
0.0096 |
2.53 |
1.23-5.30 |
| TA |
0.286 |
0.456 |
|
|
|
0.304 |
|
|
|
| TT |
0.071 |
0.142 |
|
|
|
0.065 |
|
|
|
|
IL1B rs16944 |
|
|
|
|
|
|
|
|
|
| GA |
0.535 |
0.449 |
|
|
|
0.583 |
|
|
|
| GG |
0.442 |
0.364 |
|
|
|
0.375 |
|
|
|
| AA |
0.023 |
0.188 |
0.015 |
0.10 |
0.00-0.66 |
0.042 |
0.024 |
0.19 |
0.02-0.79 |
|
IL8 rs4073 |
|
|
|
|
|
|
|
|
|
| AT |
0.659 |
0.445 |
0.0231 |
2.40 |
1.12-5.32 |
0.500 |
|
|
|
| AA |
0.244 |
0.396 |
|
|
|
0.386 |
|
|
|
| TT |
0.098 |
0.159 |
|
|
|
0.114 |
|
|
|
|
IL6 rs1818879 |
|
|
|
|
|
|
|
|
|
| GG |
0.439 |
0.268 |
|
|
|
0.381 |
|
|
|
| AG |
0.390 |
0.530 |
|
|
|
0.452 |
|
|
|
| AA |
0.171 |
0.202 |
|
|
|
0.167 |
|
|
|
|
LTA rs909253 |
|
|
|
|
|
|
|
|
|
| CT |
0.535 |
0.244 |
0.0004 |
3.56 |
1.68-7.54 |
0.540 |
0.00014 |
3.63 |
1.79-7.38 |
| TT |
0.302 |
0.488 |
0.0432 |
0.45 |
0.20-0.97 |
0.320 |
0.0517* |
0.49 |
0.24-1.00 |
| CC |
0.163 |
0.267 |
|
|
|
0.140 |
|
|
|
|
TNF |
|
|
|
|
|
|
|
|
|
| rs361525 |
|
|
|
|
|
|
|
|
|
| GG |
0.818 |
0.884 |
|
|
|
0.894 |
|
|
|
| AA |
0.136 |
0.006 |
0.00031 |
27.0 |
3.07-1248.77 |
0.000 |
|
|
|
| GA |
0.045 |
0.110 |
|
|
|
0.106 |
|
|
|
| rs1800629 |
|
|
|
|
|
|
|
|
|
| GG |
0.932 |
0.946 |
|
|
|
0.911 |
|
|
|
| GA |
0.068 |
0.054 |
|
|
|
0.089 |
|
|
|
| AA |
0.000 |
0.000 |
|
|
|
|
|
|
|
| rs1800750 |
|
|
|
|
|
|
|
|
|
| GG |
0.789 |
0.949 |
0.0035 |
0.20 |
0.06-0.66 |
0.830 |
0.0116 |
0.26 |
0.08-0.84 |
| AA |
0.158 |
0.028 |
0.005 |
6.41 |
1.51-27.92 |
0.128 |
0.0128 |
5.00 |
1.20-21.61 |
| GA | 0.053 | 0.023 | 0.043 | ||||||
A/H1N1 group: patient infected with influenza A/H1N1 virus; AHC group: asymptomatic, healthy contacts; ILI group: patients with influenze-like illness; OR: odds ratio; CI: confidence interval. Results were considered statistically significant when p was <0.05.