Table 5.
Risk of influenza A/H1N1 infection in relation to the different polymorphisms studied
|
Gen/allele |
Risk of influenza A/H1N1 infection |
||
|---|---|---|---|
| p | OR (95% CI) | OR allelic (95% CI) | |
|
CCL1 |
|
|
2.31 (1.25-4.31) |
| rs2282691 |
|
|
|
| AT |
0.85 |
1.14 (0.29-4.38) |
|
| AA |
0.12 |
2.75 (0.78-9.72) |
|
|
IL1B |
|
|
1.62 (0.92-2.88) |
| rs16944 |
|
|
|
| GG |
0.04 |
8.57 (1.11-66.46) |
|
| AG |
0.06 |
7.33 (0.95-56.41) |
|
|
IL8 |
|
|
1.45 (0.80-2.63) |
| rs4073 |
|
|
|
| TT |
0.96 |
0.97 (0.29-3.28) |
|
| AT |
0.17 |
1.73 (0.79-3.74) |
|
|
IL6 |
|
|
1.01 (0.59-1.71) |
| r1818879 |
|
|
|
| AG |
0.2 |
0.61 (0.29-1.30) |
|
| AA |
0.45 |
0.69 (0.26-1.82) |
|
|
LTA |
|
|
0.72 (0.42-1.26) |
| rs909253 |
|
|
|
| GG |
0.66 |
1.25 (0.46-3.41) |
|
| AG |
<0.001 |
3.3 (1.51-7.20) |
|
|
TNF |
|
|
1.25 (0.79-1.99) |
| rs1800750 |
|
|
|
| AG |
0.27 |
2.54 (0.49-13.24) |
|
| AA |
0.02 |
3.52 (1.24-10.03) |
|
| rs1800629 |
|
|
1.10 (0.30-3.91) |
| AG |
0.88 |
1.1 (0.30-4.02) |
|
| rs361525 |
|
|
3.34 (1.56-7.08) |
| AG |
0.37 |
0.5 (0.11-2.24) |
|
| AA | <0.001 | 34.8 (4.06-297.87) | |
OR: odds ratio; CI: confidence interval; allelic OR: comparison with ancestral gene. Results were considered statistically significant when P was <0.05.