Table 3.
Accessory regions identified among S. pneumoniae isolates
| Accessory Region | TIGR4 locus | Gene annotation |
|---|---|---|
| AR1 |
SP0482 |
hypothetical protein |
| |
SP0483 |
ABC transporter, ATP-binding protein |
| |
SP0484 |
hypothetical protein |
| AR2 |
SP1050 |
transcriptional regulator, putative |
| |
SP1051 |
hypothetical protein |
| |
SP1052 |
phosphoesterase, putative |
| AR3 |
SP1062 |
ABC transporter, ATP-binding protein |
| |
SP1063 |
ABC-2 transporter, permease protein, putative |
| |
SP1064 |
transposase, IS200 family |
| AR4 |
SP1129 |
integrase/recombinase, phage integrase family |
| |
SP1130 |
transcriptional regulator |
| |
SP1131 |
transcriptional regulator, putative |
| AR5 |
SP1134 |
hypothetical protein |
| |
SP1135 |
hypothetical protein |
| |
SP1136 |
hypothetical protein |
| |
SP1137 |
GTP-binding protein, putative |
| AR6 |
SP1315 |
V-type ATP synthase subunit D |
| |
SP1316 |
V-type ATP synthase subunit B |
| |
SP1317 |
V-type ATP synthase subunit A |
| |
SP1318 |
V-type ATP synthase subunit F |
| |
SP1319 |
V-type sodium ATP synthase, subunit C |
| |
SP1320 |
V-type sodium ATP synthase, subunit E |
| |
SP1321 |
V-type ATP synthase subunit K |
| |
SP1322 |
V-type ATP synthase subunit I |
| |
SP1323 |
hypothetical protein |
| |
SP1324 |
ROK family protein |
| |
SP1325 |
oxidoreductase, Gfo/Idh/MocA family |
| |
SP1326 |
neuraminidase, putative |
| |
SP1327 |
hypothetical protein |
| |
SP1328 |
sodium: solute symporter family protein |
| |
SP1329 |
N-acetylneuraminate lyase |
| |
SP1330 |
N-acetylmannosamine-6-phosphate 2-epimerase |
| |
SP1331 |
phosphosugar-binding transcriptional regulator, putative |
| AR7 |
SP1341 |
ABC transporter, ATP-binding protein |
| |
SP1342 |
toxin secretion ABC transporter, ATP-binding/permease protein |
| |
SP1343* |
prolyl oligopeptidase family protein |
| |
SP1344* |
hypothetical protein |
| AR8 |
SP1433 |
transcriptional regulator, AraC family |
| |
SP1434* |
ABC transporter, ATP-binding/permease protein |
| |
SP1435 |
ABC transporter, ATP-binding protein |
| |
SP1436 |
hypothetical protein |
| AR8 |
SP1437 |
hypothetical protein |
| |
SP1438 |
ABC transporter, ATP-binding protein |
| AR9 |
SP1616 |
allulose-6-phosphate 3-epimerase |
| |
SP1617 |
PTS system, IIC component |
| |
SP1618 |
PTS system, IIB component |
| |
SP1619 |
PTS system, IIA component |
| |
SP1620 |
PTS system, nitrogen regulatory component IIA |
| |
SP1621 |
putative transcription anti terminator BglG family protein |
| |
SP1622 |
transposase, IS200 family |
| AR10 |
SP1738 |
guanylate kinase |
| |
SP1739 |
hypothetical protein |
| |
SP1740 |
hypothetical protein |
| AR11 |
SP1856* |
transcriptional regulator, MerR family |
| |
SP1857 |
cation efflux system protein |
| |
SP1858 |
transcriptional regulator, TetR family |
| |
SP1859* |
transporter, putative |
| |
SP1860 |
choline transporter |
| AR12 |
SP1896* |
sugar ABC transporter, permease protein |
| |
SP1897 |
sugar ABC transporter, sugar-binding protein |
| |
SP1898* |
alpha-galactosidase |
| AR13 |
SP2159 |
fucolectin-related protein |
| |
SP2160 |
hypothetical protein |
| |
SP2161 |
PTS system, IID component |
| |
SP2162 |
PTS system, IIC component |
| SP2163 | PTS system, IIB component |
* contain virulence genes identified by signature tagged mutagenesis [41].