Table 2.
Humoral and cellular immune responses
| Chronic fatigue syndrome patients (n=20) | Healthy controls (n=20) | p-value | |
|---|---|---|---|
|
Seroprotection rate pre-vaccination (day 1) | |||
| H3N2 |
13 (65) |
12 (60) |
0.744 |
| H1N1 |
4 (20) |
5 (25) |
0.705 |
| B |
16 (80) |
17 (85) |
0.677 |
| H3N2, H1N1, and B |
2 (10) |
4 (20) |
0.376 |
|
Seroprotection rate post-vaccination (day 22) | |||
| H3N2 |
18 (90) |
20 (100) |
0.147 |
| H1N1 |
18 (90) |
18 (90) |
1.000 |
| B |
18 (90) |
20 (100) |
0.147 |
| H3N2, H1N1, and B |
15 (75) |
18 (90) |
0.212 |
|
Seroresponse rate post-vaccination (day 1 to 22) | |||
| H3N2 |
10 (50) |
12 (60) |
0.525 |
| H1N1 |
13 (65) |
12 (60) |
0.744 |
| B |
2 (10) |
3 (15) |
0.633 |
| H3N2, H1N1, and B |
1 (5) |
2 (10) |
0.548 |
|
IL-10 production at baseline (day 1, pg/ml) | |||
| H3N2 |
4.5±10.9 |
2.5±5.0 |
0.457 |
| H1N1 |
65.6±127.4 |
35.3±47.2 |
0.329 |
| B |
19.3±56.0 |
10.5±20.2 |
0.514 |
|
Treg at baseline (day 1, %) | |||
| Unstimulated |
2.8±1.2 |
2.7±1.5 |
0.733 |
|
IFN-γ production post-vaccination (day 8, pg/ml) | |||
| H3N2 |
162.1±220.5 |
116.0±180.8 |
0.474 |
| H1N1 |
578.3±828.8 |
382.5±446.1 |
0.360 |
| B |
316.4±520.7 |
418.1±528.9 |
0.544 |
|
IL-4 production post-vaccination (day 8, pg/ml) | |||
| H3N2 |
0.0±0.0 |
4.3±13.5 |
0.169 |
| H1N1 |
0.0±0.0 |
7.7±20.2 |
0.105 |
| B |
2.9±8.8 |
0.0±0.0 |
0.163 |
|
IL-5 production post-vaccination (day 8, pg/ml) | |||
| H3N2 |
1.4±4.3 |
1.7±4.7 |
0.811 |
| H1N1 |
1.2±3.4 |
1.5±4.5 |
0.788 |
| B | 0.8±3.4 | 3.4±6.4 | 0.114 |
Data are presented as absolute numbers with percentages in brackets or as mean ± standard error of the mean.