. 2012 Dec 2;1:61. doi: 10.1186/2046-4053-1-61

Table 1.

Most commonly used therapies for treatment of diabetic neuropathy

Class	Medication	Minimum effective dose (total daily dose)
Tricyclics	Amitriptyline	50 mg
	Desipramine	100 mg
	Imipramine	100 mg
	Nortriptyline	50 mg
Selective serotonin reuptake inhibitors	Duloxetine	60 mg
	Paroxetine	40 mg
	Venlafaxine^a	75 mg
Anticonvulsants	Carbamazepine	600 mg
	Gabapentin	900 mg
	Lamotrigine^a	100 mg
	Oxcarbazepine^a	600 mg
	Pregabalin	150 mg
	Sodium valproate^a	400 mg
	Topiramate^a	100 mg
Topical analgesics	Capsaicin 0.0075%
	Doxepin^a
	Lidocaine 5% patch^a
	Mexiletine^a
	Pentoxifyline^a
Analgesic opiates	Morphine^a	15 mg
	Oxycodone	20 mg
	Tapentadol^a	100 mg
	Tramadol	100 mg
Aldose reductase inhibitors^a	Epalrestat	150 mg
	Ranirestat	20 mg
	Fidarestat	1 mg
	Ponalrestat	600 mg
	Sorbinil	250 mg
Various	Lacosamide^a	100 mg

^aNo dose recommended by the American Diabetes Association.