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The reduction of fibrosis in intercrossed Sgcg animals is specific to the MRL genome. Hydroxyproline (HOP) is a measure of fibrosis and is represented on the y axis (mM/mg). Fibrosis is significantly reduced in the heart (***p < 0.001), diaphragm (p < 0.001), quadriceps (*p = 0.041) and abdominal muscles (p < 0.001) of Sgcg animals intercrossed in the D2/MRL background compared to those intercrossed in the D2/129 background.
