Figure 6. ER stress.

Variations in pro- and activated caspase-12 levels in the frontal cortex, amygdala, hippocampus and hypothalamus, determined in rats by western blot 6 weeks after oAβ_25–35 icv injection (10 µg/rat). Pro-caspase-12 (50 kDa) and activated caspase-12 (25 kDa) variations were normalized with β-tubulin (β-tub, 55 kDa) variations and compared with untreated rats (control group: C). The results are expressed as means ± SEM. *p<0.05 and **p<0.01 vs. control group, +p<0.05 and ++p<0.01 vs. scrambled treated rats. Note that scrambled peptide injection (10 µg/rat) served as negative control and did not induce any modifications in pro- and activated caspase-12 levels. The number of animals in each group is indicated within the columns.