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. 2013 Jan 2;8(1):e53117. doi: 10.1371/journal.pone.0053117

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© 2013 Zussy et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Effects of oAβ_25–35 (10 µg/rat) icv injection on APP processing in the frontal cortex, amygdala, hippocampus and hypothalamus, determined by western blot in untreated control rats and 6 weeks after Aβ_25–35 scrambled amyloid peptide (10 µg/rat; negative control) or oAβ_25–35 injection. APP (125 KDa) and C99 (13 KDa) variations were normalized with β-tubulin (β-tub, 55 KDa) variations and compared with non-injected rats (control group: C). The results are expressed as means ± SEM. *p<0.05 and **p<0.01 vs. control non-injected rats (control group: C) and +p<0.05 and ++p<0.01 vs. respective scrambled peptide-treated rats. The number of animals in groups is indicated within the columns.