Table 3. Results from the piece-wise linear model for CD4 response after ART initiation.
Group | Baseline | Six weeks after ART | One year after ART |
CD4 count (95% CI1) | CD4 count (95% CI) | CD4 count (95% CI) | |
TB group (overall)<50 cells/ml50–199 cells/ml≥200 cells/ml | 80 (75–86)17 (15–19)109 (100–119)297 (250–348) | 200 (162–242)118 (91–149)232 (184–286)375 (267–501) | 251 (210–295)172 (138–211)279 (230–333)414 (315–528) |
Non-TB group (overall)<50 cells/ml50–199 cells/ml≥200 cells/ml | 107 (101–113)21 (18–23)118 (112–123)311 (264–362) | 221 (197–245)120 (96–146)234 (205–266)377 (291–475) | 269 (246–293)173 (145–203)280 (251–310)415 (336–502) |
Confidence intervals were derived based on the delta method of approximation, using estimates of the variance of the parameters produced by the GEE model. Note that the overall differences in CD4 counts present in the TB versus non-TB groups, are not evident among the three CD4 groupings suggesting that differences in CD4 response are a function of higher rates of baseline immunosuppression among TB patients rather than an independent TB-associated effect.