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. 2013 Jan 2;8(1):e53444. doi: 10.1371/journal.pone.0053444

Figure 4. Immunoblotings showing the effects of neuregulin β1 (NRG β1) on tyrosine phosphorylation of erbB2 receptor at different time points.

Figure 4

Note that NRG β1 significantly induces rapid tyrosine phosphorylation of membrane protein (detected by 4G10 antibody) at 185 kDa (A). The 4G10-reactive phosphorylated protein at 185 kDa was further validated to be erbB2 receptor by immunoprecipitating with anti-erbB2 antibody and followed by Western blot analysis (B). The β-actin was used as an internal loading control.