Table 2. Exposure to clarithromycin in the first trimester.

Type of major malformation	Number of offspring diagnosed with a major malformation		Odds ratio (CI95%)
	Exposed N = 253	Unexposed N = 705 584	Unadjusted	adjusted
Congenital malformations of the nervous system	0 (0.0)	886 (0.1)	–	–
Neural Tube Defects	0 (0.0)	292 (0.0)
Congenital malformations of the eye	0 (0.0)	950 (0.1)	–	–
Congenital malformations of the ear, face and neck	0 (0.0)	439 (0.1)	–	–
Congenital malformations of the heart	2 (0.8)	5286 (0.8)	1.06 (0.26–4.25)	1.04 (0.26–4.17)
Oro-facial clefts	0 (0.0)	1295 (0.2)	–	–
Congenital malformations of the digestive system	0 (0.0)	1277 (0.2)	–	–
Congenital malformations of the internal urinary system	0 (0.0)	1819 (0.3)	–	–
Congenital malformations of the external genital organs	2 (0.8)	2077 (0.3)	2.70 (0.67–10.86)	2.86 (0.71–11.51)
Congenital malformations of the limbs	5 (2.0)	7509 (1.1)	1.88 (0.77–4.55)	1.97 (0.81–4.78)
Congenital malformations of the musculoskeletal system	0 (0.0)	1179 (0.2)	–	–
Chromosomal abnormalities	0 (0.0)	983 (0.1)	–	–
Teratogenic syndromes with malformations	0 (0.0)	63 (0.0)	–	–
Genetic syndromes and microdeletions	0 (0.0)	529 (0.1)	–	–
Other malformations	0 (0.0)	1131 (0.2)	–	–
Congenital malformations of the respiratory system	0 (0.0)	638 (0.1)	–	–
Abdominal wall defects	0 (0.0)	178 (0.0)	–	–
All major congenital malformations	9 (3.6)	24 808 (3.5)	1.01 (0.52–1.97)	1.03 (0.53–2.00)

CI95%, 95% confidence intervals.