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View full-text article in PMC

. 2013 Jan 2;8(1):e53259. doi: 10.1371/journal.pone.0053259

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© 2013 Le Coadic et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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According to the results of this study, Phg1A and B proteins regulate lysosomal physiology (pH, enzymes), but this has a limited impact on intracellular killing of bacteria. The primary role of Phg1 proteins in intracellular killing is to control the cellular amount of Kil1. Kil1 is necessary for efficient intracellular killing, although it precise role in this process remains to be established. Kil2 independently controls intraphagosomal magnesium levels and protease activity. The effect of Phg1 proteins on cellular adhesion is due to their role in controlling surface expression of SibA.