Skip to main content
. Author manuscript; available in PMC: 2013 Jan 3.
Published in final edited form as: Mol Cell Endocrinol. 2009 Jul 1;311(1-2):126–134. doi: 10.1016/j.mce.2009.06.011

Figure 4. Effect of kisspeptin on GnRH secretion and GnRH mRNA expression in GT1-7 and GN11 cells.

Figure 4

(A) Detailed representation of the cell treatment regimen paradigm. (B and C) Graphic representation of means±SE of relative secreted GnRH levels in GT1-7 and GN11 cells respectively, graphed as fold increases relative to non-treated cells. (D and E) Graphic representation of the means±SE of relative mRNA levels in GT1-7 and GN11 cells graphed as fold increasing of levels relative to non-treated cells. Cells were treated with 10−8M estradiol (E2 10−8M), 10−9M kisspeptin (Ks 10−9M) or co-treated with 10−9M kisspeptin in the presence of 10−8M estradiol (E2+Ks). There is no statistical difference between groups with the same letters (n=4–7, P≤0.05; ANOVA followed by Newman–Keuls test).