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. Author manuscript; available in PMC: 2013 Oct 11.
Published in final edited form as: J Phys Chem B. 2012 Oct 1;116(40):12095–12104. doi: 10.1021/jp304298c

Figure 4.

Figure 4

Thermodynamics of Trpcage stability in presence of TMAO. (A) Temperature dependence of the ellipticity of Trp-cage at different concentrations of TMAO. Solid lines show the results of the fit to a two-state model with the parameters Tm, ΔH(Tm), and ΔG(25°C) shown in (B),(C) and (D) respectively. The solid line in (D) shows the linear regression fit to the data, and the slope of the line corresponds to m-value for TMAO and is estimated to be 0.30 ± 0.15 kJ/(mol M). ±