Table 3.
Clinical and demographic variables affecting baseline performance
| EIQ |
VABS Com |
|||
|---|---|---|---|---|
| Variable | Intercept (95% CI) | P | Intercept (95% CI) | P |
| Age at RT* | 87.14 (82.22–92.06) | <.001‡ | 96.86 (92.90–100.82) | .986 |
| No. of surgeries† | 104.44 (95.80–113.08) | .036‡ | 108.35 (102.45–114.25) | <.001‡ |
| Sex | .495 | .118 | ||
| Male | 94.52 (89.50–99.54) | 94.83 (91.11–98.55) | ||
| Female | 97.05 (91.86–102.24) | 99.09 (95.31–102.87) | ||
| Extent of surgery | .999 | .628 | ||
| STR | 95.59 (84.30–106.88) | 93.81 (85.62–102.00) | ||
| NTR | 95.74 (82.06–109.42) | 94.57 (83.83–105.31) | ||
| GTR | 95.76 (91.76–99.76) | 97.59 (94.65–100.53) | ||
| Pre-RT chemotherapy | .020‡ | .006‡ | ||
| Yes | 87.84 (80.41–95.30) | 90.34 (85.09–95.59) | ||
| No | 98.04 (94.02–102.06) | 99.03 (96.05–102.01) | ||
| Shunt placement | <.001‡ | <.001‡ | ||
| Yes | 86.46 (80.58–92.34) | 90.17 (85.94–94.40) | ||
| No | 100.67 (96.51–104.83) | 100.82 (97.68–103.96) | ||
| VABS DL |
VABS Soc |
VABS ABC |
|||
|---|---|---|---|---|---|
| Intercept (95% CI) | P | Intercept (95% CI) | P | Intercept (95% CI) | P |
| 86.95 (83.11–90.79) | <.001‡ | 93.82 (90.49–97.15) | .003‡ | 88.09 (83.90–92.28) | .004‡ |
| 102.48 (96.07–108.89) | .001‡ | 106.09 (100.70–111.48) | .001‡ | 105.76 (99.21–112.31) | <.001‡ |
| .057§ | .480 | .222 | |||
| 89.94 (86.04–93.84) | 96.69 (93.38–100.00) | 90.89 (86.73–95.05) | |||
| 95.38 (91.42–99.34) | 98.40 (95.03–101.77) | 94.60 (90.39–98.81) | |||
| .046‡ | .463 | .195 | |||
| 82.79 (74.44–91.14) | - | 93.69 (86.48–100.90) | 84.94 (75.94–93.94) | ||
| 96.92 (85.87–107.97) | .048 | 95.11 (85.39–104.83) | 91.78 (79.98–103.58) | ||
| 93.59 (90.59–96.59) | .019 | 98.16 (95.55–100.77) | 93.79 (84.79–102.79) | ||
| .008‡ | <.001‡ | <.001‡ | |||
| 85.96 (80.43–91.49) | 89.94 (85.45–94.43) | 83.16 (77.48–88.64) | |||
| 94.77 (91.63–97.91) | 100.00 (97.43–102.57) | 95.80 (92.57–99.03) | |||
| <.001‡ | <.001‡ | <.001‡ | |||
| 83.84 (79.51–88.17) | 91.17 (87.41–94.93) | 82.73 (78.24–87.22) | |||
| 97.53 (94.34–100.72) | 101.07 (98.33–103.81) | 98.32 (95.01–101.63) | |||
Abbreviations: ABC = Adaptive Behavior Composite; CI = confidence interval; Com = Communication Index; DL = Daily Living Skills Index; EIQ = estimated IQ; GTR = gross total resection macroscopic complete); NTR = near total resection (≤5-mm residual disease); RT = conformal and intensity modulated radiation therapy; SEM = standard error of the mean; Soc = Socialization Index; STR = subtotal resection (>5-mm residual disease); VABS = Vineland Adaptive Behavior Scales.
Clinical and demographic variables are included in this table if their relationship with IQ and VABS scores was significant or trended toward significance in univariate models.
Younger age at RT was associated with lower scores, such that scores increased significantly with each additional year of age at the time of RT for EIQ, VABS DL, VABS Soc, and VABS ABC.
More than one surgery was associated with significantly lower scores across EIQ and all VABS indices, where scores worsened with each additional surgery.
Significant at a P value of <.05.
Nonsignificant trend at a P value of <.10.