Table 4.
Patient characteristics in low-grade glioma (chemotherapy vs no chemotherapy)
| Variable | No. of patients who had pre-CRT chemotherapy (n=16) (%) |
No. of patients who did not have chemotherapy (n=41) (%) |
P value |
|---|---|---|---|
| Tumor location | |||
| Infratentorial | 2 (12.5) | 11 (26.8) | .31 |
| Supratentorial | 14 (87.5) | 30 (73.2) | |
| Hydrocephalus | |||
| Yes | 5 (31.3) | 15 (36.6) | .70 |
| No | 11 (68.8) | 26 (63.4) | |
| CSF shunting | |||
| No | 9 (56.3) | 28 (68.3) | .39 |
| Yes | 7 (43.8) | 13 (31.7) | |
| Pre-CRT progression | |||
| No | 2 (12.5) | 14 (34.1) | .19 |
| Yes | 14 (87.5) | 27 (65.9) | |
| Extent of resection | |||
| Bx or NBx | 10 (62.5) | 24 (58.5) | .78 |
| GTR, NTR, STR | 6 (37.5) | 17 (41.5) | |
| No. of pre-CRT surgeries | |||
| 0–1 | 12 (75.0) | 32 (78.0) | 1.0 |
| 2–3 | 4 (25.0) | 9 (22.0) | |
| Mean±SD age at diagnosis (y) | 3.6±2.9 | 8.3±3.6 | <.0001†‡* |
| Mean±SD age at CRT (y) | 7.5±2.6 | 9.5±3.3 | .037†‡* |
| Mean±SD time from diagnosis to CRT (y) | 3.9±2.2 | 1.2±2.0 | <.0001†‡* |
Abbreviations CRT = conformal radiation therapy; CSF = cerebrospinal fluid; GTR = gross total resection; NTR = near-total resection; STR = subtotal resection; Bx = biopsy; NBx = no biopsy.
† P values derived either by chi-square or Fisher’s exact test* or by t test‡.