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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Heart Rhythm. 2012 Sep 14;10(1):101–107. doi: 10.1016/j.hrthm.2012.09.006

Figure 2.

Figure 2

Effect of carvedilol analogue on diastolic SCaEs in perfused rabbit ventricles. A, Cai optical recordings during the period following the cessation of rapid ventricular pacing (S) under isoproterenol infusion (0.1 μM). (Top) Note the transient increase in Cai level (diastolic SCaE, arrowhead) after pacing. esc = escape beat. (Middle) Cai recording during VT observed following rapid pacing. This tracing was recorded at the site of the VT origin. Note that the diastolic SCaE preceded each VT beat. (Bottom) VK-II-36 (30 μM) abolished the diastolic SCaEs and VT. B, ECGs show that VK-II-36 suppressed polymorphic VT induced after the cessation of rapid ventricular pacing under isoproterenol infusion.