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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Heart Rhythm. 2012 Sep 14;10(1):101–107. doi: 10.1016/j.hrthm.2012.09.006

Figure 3.

Figure 3

Effect of carvedilol analogue on EADs and dispersion of repolarization in a rabbit model of acquired long QT syndrome. A, APD map and systolic SCaE map are shown with a local Vm and Caioptical signals obtained at sites as indicated. Phase-2 EAD (filled square) is noted at the long APD site, while phase-3 EAD (unfilled square) was detected at the boundary zone between the long and short APD sites. The sites where systolic SCaEs (red arrow) are observed correspond to the long APD sites. Note that VK-II-36 (30 μM) abolished the systolic SCaE and phase-2 EAD, resulting in a marked reduction of repolarization heterogeneity. B, Mean ± SEM values of maximal APD70, minimal APD70, and APD70 dispersion before and after the addition of VK-II-36 (n = 6). *P < 0.01.