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ACh fold-shifts for selected hM1 PAMs.
| Compd | hM1 ACh fold-shifta |
|---|---|
| ML137 | 2.7 ± 0.2 |
| 14 | 27.2 ± 0.6 |
| 23g | 7.4 ± 0.6 |
| 23h | 12 ± 2 |
| 23e | 6.5 ± 0.3 |
| 23f | 8.0 ± 0.3 |
| 23r | 15.2 ± 0.5 |
Leftward shift of an ACh CRC in the presence of 30 μM compound relative to the ACh CRC control. Values represent the mean ± standard error of the means of at least three independent determinations.
