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. Author manuscript; available in PMC: 2014 Jan 15.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Dec 1;23(2):412–416. doi: 10.1016/j.bmcl.2012.11.092

Table 3.

ACh fold-shifts for selected hM1 PAMs.

Compd hM1 ACh fold-shifta
ML137 2.7 ± 0.2
14 27.2 ± 0.6
23g 7.4 ± 0.6
23h 12 ± 2
23e 6.5 ± 0.3
23f 8.0 ± 0.3
23r 15.2 ± 0.5
a

Leftward shift of an ACh CRC in the presence of 30 μM compound relative to the ACh CRC control. Values represent the mean ± standard error of the means of at least three independent determinations.