Table 1.
Mutational effects and mutational specificity of mutL and mutL dcd strains (mutants per 108 cells)
| Mutation | mutL | mutL dcd | dcd mutator effect |
|---|---|---|---|
| lac A·T → C·G | 1.3 ± 0.3 | 4.0 ± 0.4 | 3.0 |
| lac G·C → C·G | 240 ± 85 | 1200 ± 280 | 5.0 |
| lac G·C → C·G | ≤ 0.2 | ≤ 0.8 | — |
| lac G·C → T·A | 8.0 ± 1.5 | 212 ± 94 | 27 |
| lac A·T → T·A | 3.5 ± 2.1 | 148 ± 54 | 42 |
| lac A·T → G·C | 21 ± 8 | 53 ± 10 | 2.5 |
| Rifr | 126 ± 79 | 256 ± 192 | 2.1 |
The results are the average ± S.E. for three independent experiments, each using 12-15 cultures. The dcd mutator effect is calculated as the increase in frequency in mutL dcd strains compared to the corresponding mutL strain.