Table 2.
Mutational effects and mutational specificity of mutL and mutL ndk strains (mutants per 108 cells)
| Mutation | mutL | mutL ndk | ndk mutator effect |
|---|---|---|---|
| lac A·T → C·G | 0.60 ± 3 | 0.68 ± 0.21 | 1.1 |
| lac G·C → C·G | 58 ± 6 | 100 ± 30 | 1.7 |
| lac G·C → C·G | ≤ 0.2 | ≤ 0.3 | — |
| lac G·C → T·A | 3.1 ± 0.7 | 5.8 ± 0.8 | 1.9 |
| lac A·T → T·A | 0.62 ± 0.12 | 15 ± 3 | 24 |
| lac A·T → G·C | 16 ± 3 | 40 ± 1 | 2.5 |
| Rifr | 380 ± 55 | 3900 ± 1300 | 10 |
The results are the average ± S.E. for three independent experiments, each using 12-15 cultures. The ndk mutator effect is calculated as the increase in frequency in mutL ndk strains compared to the corresponding mutL strain.