Table 3.
Clinical characteristics of 343 obese African American individuals with or without paradoxical hyperadiponectinemia
| Men | Women | |||||
|---|---|---|---|---|---|---|
| Variable | Obese without PHA (n=89) | Obese with PHA (n=21) | P-value | Obese without PHA (n=188) | Obese with PHA (n=45) | P-value |
| Age (years) | 42.3±10.6 | 45.3±10.2 | 0.25 | 41.9±9.8 | 46.7±8.9 | 0.003 |
| BMI (kg/m2) | 35.9±6.6 | 34.8±6.7 | 0.48 | 38.5±7.3 | 35.9±5.4 | 0.007 |
| PFM | 36.0±7.0 | 36.3±9.7 | 0.86 | 46.7±6.5 | 46.2±6.3 | 0.67 |
| WC (cm) | 111.7±14.2 | 107.5±15.3 | 0.23 | 107.5±13.4 | 99.8±11.8 | 0.0005 |
| WHR | 0.94±0.06 | 0.92±0.06 | 0.10 | 0.86±0.07 | 0.84±0.08 | 0.08 |
| SBP (mmHg) | 131.4±16.9 | 133.2±19.7 | 0.68 | 129.1±18.8 | 130.6±17.4 | 0.62 |
| DBP (mmHg) | 83.1±10.5 | 84.5±13.3 | 0.60 | 80.7±11.7 | 82.2±11.4 | 0.45 |
| Glucose (mg/dl) | 91.8±12.4 | 87.2±11.3 | 0.13 | 86.9±10.0 | 82.23±8.11 | 0.004 |
| Insulin (μU/ml) | 17.9±20.6 (13.2) | 12.3±7.5 (10.2) | 0.04 | 18.4±26.0 (12.9) | 8.3±4.5 (6.9) | 1.2×10-06 |
| HOMA_IR | 4.3±5.9 (3.0) | 2.7±1.8 (2.2) | 0.03 | 4.14±6.89 (2.8) | 1.68±0.9 (1.4) | 4.8×10-06 |
| HDL(mg/dl) | 41.8±9.8 | 52.2±13.4 | 0.002 | 48.1±14.4 | 62.8±13.4 | 2.13×10-09 |
| LDL-C (mg/dl) | 125.7±43.9 | 130.9±50.7 | 0.63 | 120.7±38.5 | 118.5±43.7 | 0.74 |
| TG (mg/dl) | 131.5±79.0 (114.8) | 114.2±73.0 (97.7) | 0.36 | 109.8±68.2 (97.7) | 85.4±34.2 (79.4) | 0.0008 |
| Total Cholesterol (mg/dl) | 193.8±45.7 | 206.0±55.82 | 0.30 | 190.8±42.9 | 198.4±47.3 | 0.30 |
| Adiponectin (ng/ml) | 4772.7±1746.7 (4466.8) | 11352.1±2561.0 (11220.2) | 4.0×10-11 | 5648.4±2283.0 (5128.6) | 15449.2±4242.3 (14791.1) | 3.5×10-20 |
Data is presented as mean ± standard deviation; values in parenthesis () are geometric means when variables were not normally distributed.
In females: “obese without PHA” was defined as adiponectin level below 11050.9 ng/ml and obese with PHA was defined as adiponectin level above 11050.9 ng/ml
In males: “Obese without PHA” was defined as adiponectin level below 8377.2 ng/ml and “Obese with PHA” was defined as adiponectin level above 8377.2 ng/ml
Student's -t tests were used to compare means between “obese without PHA” and “obese with PHA” within gender.