Skip to main content
. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Appl Microbiol Biotechnol. 2012 Apr 13;94(4):887–905. doi: 10.1007/s00253-012-4040-1

Figure 2.

Figure 2

Bacterial sialic acid metabolism using E. coli K1 as a model system. Abbreviations: UDP-GlcNAc, uridine 5′-diphosphate-N-acetylglucosamine; ManNAc, N-acetylmannosamine; Neu5Ac, N-acetylneuraminic acid; CMP-Neu5Ac, cytidine 5′-monophospho-N-acetylneuraminic acid; GlcNAc, N-acetylglucosamine; Fru, fructose; LPS, lipopolysaccharide; CPS, capsule polysaccharide; PSA, polysialic acid; R, LPS or CPS. Enzymes: NeuC, hydrolyzing UDP-GlcNAc 2-epimerase; NeuB, sialic acid synthase; NanA, Sialic acid aldolase; NeuA, CMP-sialic acid synthetase (NeuA in E. coli K1 and Streptococcus agalactiae also possesses O-acetylesterase activity); NeuD, sialic acid O-acetyltransferase; ST, sialyltransferase; NeuS, polysialyltransferase; NeuO, polysialic acid O-acetyltransferase; NanK, ManNAc kinase; NanE, ManNAc-6-phosphate epimerase; NagB, GlcNAc-6-phosphate deacetylase; NagA, glucosamine-6-phosphate deaminase; NanH, sialidase; NanT, Neu5Ac transporter.