Table 4.

Independent associations of moderate-to-vigorous activity and sedentary time in relation to breast cancer odds, by tumor characteristics¹

	Accelerometer measures (average minutes/day)*
Tumor characteristics (among invasive cases, n=919)	Moderate-to-vigorous Activity (≤ 65.0 as referent)				Sedentary Time (≤ 396.6 as referent)
	65.10 - 95.58	95.59 - 128.24	≥ 128.25	P-value 2	396.61- 457.74	457.75 - 524.10	≥ 524.11	P-value 2
Tumor size
≤ 2 cm	0.58 (0.41, 0.81)	0.31 (0.20, 0.48)	0.28 (0.17, 0.48)		1.47 (0.95, 2.27)	1.62 (1.02, 2.58)	2.06 (1.22, 3.47)
> 2 cm	0.66 (0.48, 0.91)	0.47 (0.33, 0.69)	0.41 (0.25, 0.65)		1.26 (0.86, 1.83)	1.36 (0.90, 2.04)	1.65 (1.04, 2.63)
Unknown	0.71 (0.44, 1.14)	0.47 (0.26, 0.85)	0.56 (0.28, 1.12)	0.94	1.34 (0.74, 2.42)	1.72 (0.92, 3.20)	1.78 (0.87, 3.66)	0.94
Tumor grade (differentiation)
Well/moderate	0.68 (0.51, 0.90)	0.43 (0.30, 0.60)	0.39 (0.26, 0.59)		1.37 (0.98, 1.93)	1.46 (1.01, 2.11)	1.92 (1.26, 2.91)
Poor	0.47 (0.30, 0.74)	0.38 (0.22, 0.63)	0.24 (0.12, 0.49)		1.10 (0.63, 1.92)	1.32 (0.74, 2.36)	1.52 (0.79, 2.94)
Unknown	0.67 (0.41, 1.08)	0.37 (0.20, 0.69)	0.54 (0.27, 1.10)	0.69	1.53 (0.82, 2.83)	1.95 (1.01, 3.73)	1.76 (0.82, 3.75)	0.63
Nodal Status
Positive	0.66 (0.47, 0.94)	0.46 (0.30, 0.70)	0.38 (0.22, 0.66)		1.76 (1.12, 2.77)	2.05 (1.26, 3.32)	2.45 (1.41, 4.23)
Negative	0.62 (0.46, 0.84)	0.36 (0.25, 0.53)	0.33 (0.21, 0.52)		1.11 (0.77, 1.60)	1.16 (0.78, 1.71)	1.50 (0.96, 2.34)
Unknown	0.61 (0.36, 1.02)	0.48 (0.26, 0.88)	0.57 (0.27, 1.20)	0.78	1.44 (0.76, 2.72)	1.92 (0.98, 3.75)	1.87 (0.86, 4.06)	0.41
ER
Positive	0.66 (0.50, 0.88)	0.35 (0.24, 0.50)	0.41 (0.26, 0.62)		1.42 (1.00, 2.03)	1.59 (1.08, 2.33)	1.95 (1.26, 3.02)
Negative	0.62 (0.42, 0.91)	0.48 (0.31, 0.77)	0.38 (0.21, 0.69)		1.34 (0.84, 2.13)	1.40 (0.85, 2.33)	1.87 (1.05, 3.33)
Unknown	0.55 (0.32, 0.93)	0.53 (0.30, 0.96)	0.28 (0.12, 0.63)	0.94	1.07 (0.54, 2.11)	1.42 (0.71, 2.82)	1.29 (0.59, 2.85)	0.67
PR
Positive	0.60 (0.43, 0.82)	0.34 (0.23, 0.51)	0.44 (0.28, 0.70)		1.51 (1.03, 2.22)	1.53 (1.01, 2.33)	1.97 (1.22, 3.17)
Negative	0.71 (0.51, 0.98)	0.42 (0.28, 0.63)	0.34 (0.21, 0.57)		1.26 (0.84, 1.89)	1.48 (0.96, 2.29)	1.80 (1.10, 2.95)
Unknown	0.55 (0.33, 0.92)	0.58 (0.33, 1.03)	0.29 (0.13, 0.65)	0.25	1.08 (0.55, 2.13)	1.48 (0.75, 2.94)	1.43 (0.66, 3.12)	0.92

^*Time spent sedentary or in moderate-to-vigorous activity calculated as the average minutes per day across valid days of wear. Categories determined by the quartile distribution among controls; behavior defined by the following counts: sedentary (0-99 counts) and moderate-to-vigorous (760+ counts); data for moderate-to-vigorous activity missing for one case.

¹Multinomial models adjusted for age, BMI, and wear time; each model includes all controls and the specific invasive cases of interest.

²P for heterogeneity