Table 2.
Self-reported gastrointestinal symptoms in relation to milk consumption for various lactase genotypes
| Gastrointestinal symptoms* | Genotype | Total | P value | |
|---|---|---|---|---|
| C/C -13910 | C/T + T/T -13910 | |||
| G/G -22018 | G/A + A/A -22018 | |||
| n/N (%) | n/N (%) | n/N (%) | ||
| ≤250 ml/day milk intake† | ||||
| Flatulence | 15/54 (28) | 9/36 (25) | 24/90 (27) | 0.77‡ |
| Bloating | 14/54 (26) | 7/36 (19) | 21/90 (23) | 0.47‡ |
| Diarrhea | 10/54 (19) | 6/36 (17) | 16/90 (18) | 0.82‡ |
| Borborygmi | 13/54 (24) | 9/36 (25) | 22/90 (24) | 0.92‡ |
| Constipation | 7/54 (13) | 2/36 (5.6) | 9/90 (10) | 0.23‡ |
| >250 ml/day milk intake | ||||
| Flatulence | 42/54 (79)§ | 13/36 (36) | 55/90 (61) | <0.001‡ |
| Bloating | 19/54 (35) | 9/36 (25) | 28/90 (31) | 0.30‡ |
| Diarrhea | 13/54 (24) | 8/36 (22) | 21/90 (23) | 0.83‡ |
| Borborygmi | 19/54 (35) | 11/36 (31) | 30/90 | 0.64‡ |
| Constipation | 7/54 (13) | 2/36 (5.6) | (33) 9/90 (10) | 0.23‡ |
* Self-reported gastrointestinal symptoms
†Approximately one cup or less of milk per day
‡P value based on χ2 test
§Significantly different from number of flatulence cases in ≤ 250 ml/day milk intake group for C/C -13910 and G/G -22018 lactase genotypes (P < 0.001)