Table I.

Noncompartmental Pharmacokinetic Parameters

Parameter (units)	Bolus dose (μg)			Infusion dose (μg)
	30 (n = 6)	100 (n = 6)	300 (n = 6)	30 (n = 6)	100 (n = 6)	300 (n = 6)
AUC (pmol min/L)	5,410 ± 2,030	28,200 ± 4,830	78,900 ± 14,200	71,40 ± 1720	25,400 ± 5,950	94,100 ± 12,100
V (L)	50.7 ± 48.7	37.2 ± 12.6	32.8 ± 5.89	35.9 ± 15.7	43.4 ± 15.1	32.9 ± 11.4
CL (L/min)	1.90 ± 1.62	0.923 ± 0.179	0.984 ± 0.141	1.12 ± 0.287	1.04 ± 0.252	0.819 ± 0.110
C max (pmol/L)	304 ± 141	1300 ± 322	3700 ± 610	67.5 ± 8.72	221 ± 35.9	827 ± 97.9
t max (min)	4 ± 3	6 ± 2	7 ± 0	90 ± 27	110 ± 25	90 ± 27
t 1/2 (min)	22.5 ± 5.02	55.1 ± 34.7	50.7 ±10.0	19.6 ± 2.41	36.7 ± 9.63	49.8 ± 15.8

Data are reported as mean ± SD