Table II.
Population Pharmacokinetic Parameters
| Parameter (units) | Definition | Estimate (RSE%) | IIV (RSE%) | IOV (RSE%) |
|---|---|---|---|---|
| Structural | ||||
| CL (L/min) | Clearance | 0.955 (12.4) | 19.5 (37.6) | 10.8 (25.1) |
| V 1 (L) | Central volume | 19.1 (13.3) | 23.3 (40.4) | – |
| V 2 (L) | Peripheral volume | 11.0 (11.3) | 61.8 (21.2) | – |
| CLD (L/min) | Distribution clearance | 0.283 (12.7) | – | – |
| D 1 (min) | Duration of short infusion | 4 | 37.2 (25.1) | |
| T lag (min) | Lag-time | 0.430 (10.9) | – | – |
| CorrCL_V1 | Correlation coefficient | 0.487 | ||
| Residual variability | ||||
| Proportional (%) | 26.2 (3.85) | |||
RSE relative standard error calculated as a standard error divided by population estimate; IIV interindividual variability, expressed as standard deviation in percent; IOV interoccasion variability, expressed as standard deviation in percent