Table IV.

Performance check of FLU and TA modules of the ICSpkTS R extension package

	FLU—simulated data	FLU—literature data (40–43)	TA—simulated data	TA—literature data (38,39,44)
	Mean	Range	Mean	Range
C max (ng/mL)	1.30	0.81–2.39	0.18	0.12–0.25
t max (h)	0.33	0.09–0.2	2.01	1.59–3.67
AUC0−inf (ng mL−1 h)	1.92	1.52–4.28	0.90	0.69–1.92

Comparison of PK metrics from simulated data using the PK trial simulation tool (mean) and literature (range of means). AUC_0−inf and C _max data from literature were normalized to the simulated dose of 250 and 100 mcg for FLU and TA, respectively