TABLE 1.
Expression Ratio for Genes of Interest
| a) Features fulfilling the Min >< Max criteria | |||||
|---|---|---|---|---|---|
| Systematic name |
Gene name | Description | log2 FC tumor vs. mucosa |
P | Map |
| NM_013227 | ACAN | Aggrecan | 3.07 | 6.60E-36 | 15q26.1 |
| NM_004673 | ANGPTL1 | Angiopoietin-like 1 | −2.66 | 1.22E-37 | 1q25.2 |
| NM_018270 | ANO5 | Anoctamin 5 | −2.9 | 3.78E-32 | 11p14.3 |
| NM_018270 | C20orf20 | Chromosome 20 open reading frame 20 | 1.67 | 1.05E-33 | 20q13.33 |
| NM_018140 | CEP72 | Centrosomal protein 72kDa | 1.95 | 5.92E-35 | 5p15.33 |
| NM_021101 | CLDN1 | Claudin 1 | 4.29 | 5.01E-48 | 3q28-q29 |
| NM_015036 | ENDOD1 | Endonuclease domain containing 1 | −1.91 | 6.00E-37 | 11q21 |
| NM_001079675 | ETV4 | Ets variant 4 | 3.25 | 1.26E-41 | 17q21 |
| NM_001079675 | ETV4 | Ets variant 4 | 2.97 | 9.72E-39 | 17q21 |
| NM_001445 | FABP6 | Fatty acid binding protein 6, ileal | 4.82 | 4.94E-43 | 5q33.3-q34 |
| NM_000148 | FUT1 | Fucosyltransferase 1 | 2.49 | 2.00E-35 | 19q13.3 |
| NM_003641 | IFITM1 | Interferon induced transmembrane protein 1 (9-27) |
2.82 | 1.36E-38 | 11p15.5 |
| NM_021034 | IFITM3 | Interferon induced transmembrane protein 3 (1-8U) |
2.68 | 2.72E-38 | 11p15.5 |
| NM_006790 | MYOT | Myotilin | −1.91 | 3.97E-41 | 5q31 |
| NM_005012 | ROR1 | Receptor tyrosine kinase-like orphan receptor 1 |
−1.67 | 9.35E-38 | 1p32-p31 |
| NM_005012 | ROR1 | Receptor tyrosine kinase-like orphan receptor 1 |
−1.81 | 1.32E-35 | 1p32-p31 |
| NM_003759 | SLC4A4 | Solute carrier family 4, sodium bicarbonate cotransporter, member 4 |
−4.81 | 8.58E-30 | 4q21 |
| NM_006714 | SMPDL3A | Sphingomyelin phosphodiesterase, acid- like 3A |
−2.53 | 3.09E-34 | 6q22.31 |
| NM_021158 | TRIB3 | Tribbles homolog 3 (Drosophila) | 3.51 | 3.07E-41 | 20p13-p12.2 |
| b) Genes being differentially expressed between KRAS WT and KRAS mutant. | |||||
|---|---|---|---|---|---|
| Systematic name |
Gene name | Description | log2 FC WT vs. mutant |
P | Map |
| NM_000719 | CACNA1C | Calcium channel, voltage dependent, L type, alpha 1C subunit |
1.2 | 2.16E-05 | 12p13.3 |
| NM_003217 | TEGT | Testis enhanced gene transcript (BAX- inhibitor-1) |
0.54 | 4.75E-06 | 12q12-q13 |
| NM_016057 | COPZ1 | Coatomer protein complex, subunit zeta 1 |
0.52 | 7.25E-07 | 12q13.2- q13.3 |
| NM_172240 | WDR51B | WD repeat domain 51B | 0.6 | 2.21E-06 | 12q21.33 |
| NM_206819 | MYBPC1 | Myosin binding protein C, slow type | 0.68 | 3.86E-06 | 12q23.2 |
| NM_020672 | S100A14 | S100 calcium binding protein A14 | 0.94 | 1.02E-06 | 1q21.3 |
| NM_018178 | GOLPH3L | Golgi phosphoprotein 3 like | 0.57 | 1.73E-05 | 1q21.3 |
| NM_001001552 | LEMD1 | LEM domain containing 1 | 2.02 | 7.58E-07 | 1q32.1 |
| NM_022743 | SMYD3 | SET and MYND domain containing 3 | 0.49 | 3.40E-06 | 1q44 |
| NM_144659 | TCP10L | T-complex 10 (mouse)-like | 0.52 | 1.57E-05 | 21q22.11 |
| NM_030666 | SERPINB1 | Serpin peptidase inhibitor, clade B (ovalbumin), member 1 |
0.56 | 1.32E-05 | 6p25 |
| NM_001394 | DUSP4 | Dual specificity phosphatase 4 | 0.9 | 1.10E-05 | 8p12-p11 |
| NM_138969 | RDHE2 | Epidermal retinal dehydrogenase 2 | 1.26 | 1.22E-06 | 8q12.1 |
FC, Fold Change