Fig. 2.

Comparison of diagnostic accuracies of pleural IL-33, pleural fluid-to-serum (P/S) IL-33 ratio, and other markers in pleural effusions for discriminating between TPEs and non-TPEs using ROC curves. Small closed circles indicate cut-offs that were determined by the highest Youden index. A small open circle on the ADA curve (blue dotted line) indicates the cut-off value (30 IU/mL) that presented in studies [30] that used the same manufacturer's reagent.

^*P<0.05, IL-33 vs. ADA; ^†P<0.05, IL-33 vs. IFN-γ.

Abbreviations: TPE, tuberculous pleural effusion; AUC, area under the ROC curve; Sens, sensitivity; Spec, specificity; ADA, adenosine deaminase; IFN-γ, interferon gamma.