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. Author manuscript; available in PMC: 2013 Jan 3.
Published in final edited form as: Sci Transl Med. 2012 Jan 25;4(118):118ra11. doi: 10.1126/scitranslmed.3002629

Fig. 5.

Fig. 5

Protection against IR by pharmacological activation of the AASR. Preconditioning with HF for 3 to 6 days protected against renal IR. (A) Serum creatinine before (0 hours) or 8 to 24 hours after 25 min of bilateral renal IR (n = 5 per group). (B) Gene expression changes in liver (top) and kidney (bottom) upon 3 days of HF treatment as measured by qPCR and presented relative to the vehicle-treated group (n = 4 to 5 per group). (C)Complete blood cell counts upon 3 days of HF treatment expressed as a percentage of the vehicle-treated (n = 5 per group). Error bars indicate SEM. Asterisks indicate the significance of the difference between the indicated group and the vehicle-treated group by one-way ANOVA followed by Dunnett's multiple comparison test (A) or by Student's t test for effect of HF treatment (B and C). **P < 0.01; ***P < 0.001.