Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Nutlin-3 can release the p53-Mdm2 complex in mdm2 SNP309 cells. A model illustrating that in cells homozygous for G/G mdm2 SNP309, p53 transcriptional activity is blocked through a chromatin-bound inhibitory complex that might contain an alternative Mdm2 isoform. DNA damage is unable to release p53 from this complex; however, the p53-Mdm2 antagonist, Nutlin-3, activates p53 function.
