Table 2.

Compounds active in animal models of arenaviral HF

Compound	Known/suspected drug target	Structure	Infection model(s)	Selected references
ST-193	Fusion	Small molecule	LASV guinea pig	[31]
ST-294	Fusion	Small molecule	TCRV mousea	[28]
Favipiravir (T-705)	Viral polymerase	Pyrazine derivative	PICV guinea pig, PICV hamster	[38-40]
Stampidine	Viral polymerase	Nucleoside analog	LASV mouseb	[46]
5-Fluorouracil	Mutagen	Base analog	LCMV mousec	[43]
Genistein	General kinase inhibitor	Isoflavone	PIRV hamster	[51]
MY-24	SAH hydrolase	Aristermoycin derivative	TCRV mouse	[25]
Bavituximab	Phosphatidylserine	Monoclonal antibody	PICV guinea pig	[63]
E567	TLR2 signaling	Small molecule	LCMV moused	[66]
DEF201	IFN pathway	Adenovirus-vectored IFN	PICV hamster	[61]
Infergen	IFN pathway	Consensus IFN	PICV hamster	[59, 60]

^aTCRV infection of newborn mice

^bCBA mice challenged by intracerebral injection of LASV

^cLCMV persistent infection in B- and T-cell-deficient mice

^dLCMV-Armstrong infection of mice

S-adenosyl-L-homocysteine, SAH.