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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: J Neurooncol. 2012 Oct 3;110(3):349–357. doi: 10.1007/s11060-012-0979-0

Figure 2.

Figure 2

KU55933 sensitizes TMZ responsive GBM cells to TMZ treatment. The effect of KU55933 on TMZ sensitivity of U251 (A) and U87 (B) cells was assessed in a clonogenic assay. Cell survival (mean ± SEM from three independent experiments) is plotted relative to TMZ dose for treatment with or without 10 microM KU55933. (C–D) Cells were collected at indicated time points after treatment with 30 microM TMZ alone or in combination with 10 microM KU-55933, fixed, and analyzed for cell cycle distribution by flow cytometric analysis of cellular DNA content. The percent of cells in G2/M (mean ± SEM from three independent experiments) is presented.