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ATM-inhibition sensitizes TMZ responsive patient xenograft derived stem-like neurospheres to TMZ. (A–B) The effect of two ATM inhibitors, KU-55933 and CP466722 on the TMZ sensitivity of parental GBM12 and TMZ resistant GBM12TMZ neurospheres was assessed by a neurosphere formation assay. Neurosphere survival (Mean ± SEM from three independent experiments) is plotted relative to TMZ concentration with or without either KU-55933 (10 micromolar) or CP-466722 (3 micromolar).
