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. 2012 Dec 11;3:1268. doi: 10.1038/ncomms2260

Figure 6. GATA3 adopts alternate distributions in Th1 and Th2 cells.

Figure 6

(a) Venn diagram showing the distal elements occupied by T-bet in Th1 cells, GATA3 in Th1 cells and GATA3 in Th2 cells. The percentage of elements bound by GATA3 specifically in Th1 cells or specifically in Th2 cells that are also occupied by T-bet are indicated. (b) Frequency of GATA and T-box motifs at distal sites exhibiting the six observed binding combinations of T-bet and GATA3 in Th1 and Th2 cells. The percentage of random sites that contain each motif is indicated for comparison. (c) Percentage of binding sites with each combination which are coincident with a Th1-specific (red) or a Th2-specific (blue) DHS site. The percentage of random sites that are coincident with a DHS site is indicated for comparison. (d) Fold-enrichment in the number of genes overexpressed in Th1 cells compared with Th2 cells (2-fold) for genes associated with at least one or at least two elements exhibiting each of the six different transcription factor occupancy combinations. *P=2 × 10–11 (n=460), **P=3 × 10–6 (n=72), †P=4 × 10–13 (n=1,726), ††P=10–11 (n=538), ‡P=2 × 10–6 (n=436), §P=7 × 10–7 (n=950), §§P=6 × 10–5 (n=279). (e) As for d, except for genes overexpressed in Th2 cells compared with Th1 cells (2-fold). *P=2 × 10–11 (n=950), **P=3 × 10–6 (n=778), ***P=4 × 10–13 (n=153).