Fig. 4.

Time evolution of peak intensities during the reaction of cyanide binding to the metNgb forms WT_ox (a), WT_red (b), and TM (c). The time-dependent (decreasing) intensities for the M^B₈ (black circles) and M^A₅ (red circles) methyl resonances are scaled relative to the initial intensity (t = 0 min). In addition, the (increasing) intensities for the m^B₃/m^B₈ (black triangles) and h^A_2β (red triangles) resonances in cyanometNgb are also reported for WT_ox in a. The red curves and the black curves represent the best-fit exponential curves for the experimental data obtained on the A isomer and the B isomer, respectively, and the resulting time constants T are also indicated for the two conformations