Table 1.
G84E mutation of HOXB13 in prostate cancer families of International Consortium for Prostate Cancer Genetics (ICPCG)
| No. of families | No. of families with G84E carriers (%) | Subjects in families with at least one G84E carrier | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Affected | Unknown (Men) | Unknown (Women) | ||||||||
| All | European descent | All | European descent | N | No. of G84E carriers (%) | N | No. of G84E carriers (%) | N | N of G84E carriers (%) | |
| Europe | ||||||||||
| Finland, University of Tampere | 76 | 76 | 17 (22.4 %) | 17 (22.4 %) | 54 | 37 (69 %) | 69 | 22 (31 %) | 97 | 29 (30 %) |
| Sweden, Umea University | 110 | 110 | 9 (8.2 %) | 9 (8.2 %) | 17 | 13 (76 %) | 15 | 5 (33 %) | 13 | 4 (31 %) |
| Germany, University of Ulm | 378 | 378 | 13 (3.4 %) | 13 (3.4 %) | 21 | 19 (90 %) | 1 | 0 (0 %) | 2 | 0 (0 %) |
| UK, ACTANE | 145 | 142 | 5 (3.4 %) | 5 (3.5 %) | 12 | 7 (58 %) | 1 | 0 (0 %) | 1 | 0 (0 %) |
| France, CeRePP | 159 | 156 | 2 (1.3 %) | 2 (1.3 %) | 5 | 3 (60 %) | 1 | 0 (0 %) | 0 | 0 |
| North America | ||||||||||
| BC/CA/HI | 98 | 83 | 6 (6.1 %) | 6 (7.2 %) | 20 | 12 (60 %) | 7 | 1 (14 %) | 7 | 1 (14 %) |
| Fred Hutchinson Cancer Research Center | 255 | 241 | 14 (5.5 %) | 14 (5.8 %) | 45 | 25 (56 %) | 14 | 5 (36 %) | 16 | 2 (13 %) |
| Johns Hopkins Hospitala | 234 | 176 | 5 (2.1 %) | 5 (2.8 %) | 20 | 14 (70 %) | 7 | 2 (29 %) | 10 | 4 (40 %) |
| MAYO Clinic | 185 | 185 | 6 (3.2 %) | 6 (3.2 %) | 15 | 10 (67 %) | 2 | 0 (0 %) | 0 | 0 |
| University of Michigana | 317 | 282 | 11 (3.5 %) | 11 (3.9 %) | 36 | 26 (72 %) | 13 | 4 (31 %) | 5 | 2 (40 %) |
| McGill University | 18 | 17 | 1 (5.9 %) | 1 (5.9 %) | 2 | 2 (100 %) | 0 | 0 | 0 | 0 |
| North Western University | 33 | 32 | 0 (0 %) | 0 (0 %) | 0 | 0 | 0 | 0 | 0 | 0 |
| University of Utah | 348 | 348 | 21 (6 %) | 21 (6 %) | 132 | 23 (17 %) | 6 | 2 (33 %) | 11 | 3 (27 %) |
| Louisiana State University | 10 | 10 | 0 (0 %) | 0 (0 %) | 0 | 0 | 0 | 0 | 0 | 0 |
| Australia | ||||||||||
| Australia | 77 | 73 | 2 (2.6 %) | 2 (2.7 %) | 3 | 3 (100 %) | 1 | 1 (100 %) | 3 | 2 (67 %) |
| Total | 2,443 | 2,309 | 112 (4.6 %) | 112 (4.9 %) | 382 | 194 (51 %) | 137 | 42 (31 %) | 165 | 47 (28 %) |
| Totala | 1,892 | 1,851 | 96 (5.0 %) | 96 (5.2 %) | 326 | 154 (47 %) | 117 | 36 (31 %) | 150 | 41 (27 %) |
aA subset of families from these centers were included in the original discovery report (Ewing et al. 2012). These total values reflect the results obtained after omitting all families from these two centers