Beclin1−/−
|
ESC |
Die early in embryogenesis |
[28, 33] |
Beclin+/−
|
ESC |
Develop tumors, apoptotic cell death |
[28] |
Atg5−/−
|
ESC |
Autophagy-dependent defective clearance of apoptotic cell corpses during development |
[26, 43] |
Ambra1−/−
|
ESC |
Embryonic lethality |
[35] |
Ambragt/gt
|
ESC/gene-trapped allele |
Over proliferation, increased apoptosis |
[35] |
Atg7fl/fl
|
HSC/Vav |
Unable to self-renew, defective mitochondrial removal, significantly reduced myeloid and lymphoid progenitors in BM, myeloproliferation of LSK compartment, myeloid leukemia |
[12, 40, 44] |
FIP200fl/fl
|
HSC/ Tie-2 |
Embryonic lethality, HSC depletion, loss of self-renewal, block of erythroid maturation, myeloproliferation, increased mitochondrial load and DNA damage |
[45] |