Table 3.
Subgroup Analyses by Outcome—Test for Interactions
| Subgroup | LR/χ2 Test | DF | P Value | |
|---|---|---|---|---|
| mADCS-CGIC (week 12) | HTR2A (CC vs CT vs TT) | 0.16 | 2 | .92 |
| HTR2C (AA vs AC vs CC) | 3.47 | 2 | .18 | |
| HTT-LPR (LL vs SL vs SS) | 0.71 | 2 | .70 | |
| BDNF (GA vs GG) | 0.82 | 1 | .36 | |
| mADCS-CGIC (week 24) | HTR2A (CC vs CT vs TT) | 1.58 | 2 | .45 |
| HTR2C (AA vs AC vs CC) | 1.23 | 2 | .54 | |
| HTT-LPR (LL vs SL vs SS) | 3.01 | 2 | .22 | |
| BDNF (GA vs GG) | 0.76 | 1 | .38 | |
| CSDD (week 12) | HTR2A (CC vs CT vs TT) | 5.28 | 4 | .26 |
| HTR2C (AA vs AC vs CC) | 5.61 | 4 | .23 | |
| HTT-LPR (LL vs SL vs SS) | 1.32 | 4 | .86 | |
| BDNF (GA vs GG) | 1.42 | 2 | .49 | |
| CSDD (over week 24) | HTR2A (CC vs CT vs TT) | 7.21 | 4 | .12 |
| HTR2C (AA vs AC vs CC) | 1.70 | 4 | .79 | |
| HTT-LPR (LL vs SL vs SS) | 7.19 | 4 | .13 | |
| BDNF (GA vs GG) | 2.74 | 2 | .25 | |
| Remissiona (week 12) | HTR2A (CC vs CT vs TT) | 0.10 | 2 | .95 |
| HTR2C (AA vs AC vs CC) | 0.95 | 2 | .62 | |
| HTT-LPR (LL vs SL vs SS) | 0.83 | 2 | .66 | |
| BDNF (GA vs GG) | 0.14 | 1 | .70 | |
| Remissiona (week 24) | HTR2A (CC vs CT vs TT) | 0.48 | 2 | .78 |
| HTR2C (AA vs AC vs CC) | 1.42 | 2 | .49 | |
| HTT-LPR (LL vs SL vs SS) | 0.33 | 2 | .85 | |
| BDNF (GA vs GG) | 0.09 | 1 | .77 |
Abbreviations: DF, degrees of freedom; LR, Likelihood ratio; χ2, chi-square test for interactions; mADCS-CGIC, modified Alzheimer’s Disease Cooperative Study Clinical Global Impression of Change index; CSDD, Cornell Scale for Depression in Dementia.
a
Remission of depression defined as a combination of mADCS-CGIC score <2 and CSDD score <6.