Exercise and play conditions significantly increased heart rate and body temperature in both treadmill and yard play conditions, but only increased Hcrt level in the yard play condition (Fig. 1). Percent changes of the mean arterial blood pressure (MAP), heart rate (HR) and core body temperature (Temp) from control condition after 30 min of treadmill exercise at individual animal’s maximum speed (Treadmill) or after 30 min of play in the yard (Yard play). ***P < 0.0001, t-test. Baseline BP (mmHg) was 117.9 ± 5.6 for treadmill, 120.4 ± 3.1 for yard play; HR (beats/min) baseline was 107.8 ± 5.0 for treadmill, 115.5 ± 3.3 for yard, Temp (°C) baseline was 38.3 ± 0.1 for treadmill, 38.4 ± 0.1 for yard play.