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Mercury blocks the monomer channel. While AQPs are tetramers in the membrane, the monomer is the functional unit. By imposing crystal symmetry on both the apo (grey) and complex structures (blue), T183C is drawn as a tetramer in cartoon representation. Mercury-Hg1, with its proper van der Waals radius, is drawn as a sphere blocking the channel. Note there is almost no structural change to the tetrameric axis.
