Table 2.
BBB Transport of Other Endogenous Peptides/Polypeptides, Mostly Cytokines and Neurotrophins
| Category | Representative Peptide/Polypeptide |
References |
|---|---|---|
| Saturable | CNTF | [172] |
| EGF | [173] | |
| GM-CSF | [174] | |
| IFNγ | [175] | |
| IGF1 | [176] | |
| IL1α/IL1β | [85] | |
| IL1RA | [177] | |
| LHRH | [178] | |
| LIF | [179] | |
| Neuregulin1β1 | [180] | |
| PACAP38 | [181] | |
| Passive diffusion (non- saturable) |
CINC1 | [182] |
| GH | [183] | |
| IFNα | [175] | |
| IL2 | [184] | |
| IL6 | [185] | |
| IL8 | [186] | |
| PACAP27 | [181] | |
| TGFα | [187] | |
| No entry | GDNF | [188] |
| IL10 | [189] | |
| MIP1α, MIP1β | [190] | |
| PDGF-AA, PDGF-BB | [191] | |
| TGFβ | [192] | |